منابع مشابه
Sigmoid curves, non-linear double-reciprocal plots and allosterism.
1. The theory of plane curves was applied to the graphical methods used in enzyme kinetics and a mathematical analysis of the possible graph shapes is given. 2. The belief that allosterism can be inferred from steady-state data alone is subjected to criticism and the mathematical significance of sigmoid curves and non-linear double-reciprocal plots is explored. 3. It is suggested that the usual...
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NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To determine if t(2;5) is involved in cutaneous lymphoproliferative disorders, we studied 37 CD30+ cutaneous lymphoproliferations, 27 mycosis fungoides (MF), and 16 benign inflammatory disorders (BID). NPM-ALK transcripts were detected by nested reverse transcription-polymeras...
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Using a combination of array comparative genomic hybridization, mate pair and cloned sequences, and FISH analyses, we have identified in multiple myeloma cell lines and tumors a novel and recurrent type of genomic rearrangement, i.e. interchromosomal rearrangements (translocations or insertions) and intrachromosomal inversions that contain long (1-4000 kb; median ∼100 kb) identical sequences ad...
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Abstract: QQ-plots are extremely useful in univariate data analysis. In this article, Koltchinskii (1997) and Chaudhuri’s (1996) definition of multivariate quantile is used to develop analogous plots for bivariate data. Bivariate qq-plots are exhibited for comparing a sample to a given population distribution (the bivariate normal), and for comparing two or more bivariate samples. The plots are...
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Translocation, a physical movement of genetic material from one chromosome to another, can aberrantly juxtapose portions of two cellular genes. This type of fusion may disrupt cellular function by producing novel, biologically-active fused genes, or by the activation of normally quiescent growth-associated genes. Either of these mechanisms provides a putative oncogenic stimulus and, indeed, sev...
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ژورنال
عنوان ژورنال: Nephron
سال: 1985
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000183619